Figure 1 | Scientific Reports

Figure 1

From: New 2-Aryl-9-methyl-β-carbolinium salts as Potential Acetylcholinesterase Inhibitor agents: Synthesis, Bioactivity and Structure–Activity Relationship

Figure 1

Synthetic route of target compounds B1-B34 and C1. Reagents and conditions: (a) phenylhydrazine-HCl, H2O, 12 h at r.t.; (b) EtOH, con. H2SO4, reflux for 12 h; (c) R2I or R2Br, NaH, dry DMF, 0 °C; (d) LiAlH4, dry THF, 0 °C to r.t.; (e) active MnO2, CHCl3, r.t.; (f) MsCl, Et3N, LiBr, dry THF, 0 °C to r.t.; (g) R-PhNH2, TsOH·H2O, EtOH, r.t.; (h) Pd/C, acetonitrile, reflux; (i) NaBH4, EtOH, r.t.

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