Figure 1 | Scientific Reports

Figure 1

From: mGluR5 antagonism inhibits cocaine reinforcement and relapse by elevation of extracellular glutamate in the nucleus accumbens via a CB1 receptor mechanism

Figure 1

Effects of the mGluR5 antagonist MPEP on cocaine self-administration and reinstatement of drug-seeking behavior in rats. (A) Diagram showing the general experimental procedures. (B) Effects of systemic administration of MPEP (10, 20 mg/kg) on the total number of cocaine infusions during daily 3 h session; (C) Time course of cocaine self-administration within daily 3 h session, illustrating that MPEP significantly inhibited cocaine self-administration in the first hour of self-administration sessions. (D) Intra-NAc local administration of MPEP also inhibited cocaine self-administration. (E) Systemic administration of MPEP dose-dependently lowered the break-point for cocaine self-administration under PR reinforcement. (F/G) Systemic administration of MPEP failed to alter oral sucrose self-administration under FR2 reinforcement (F) but decreased the break-point for sucrose self-administration under PR reinforcement (G). (H/I/J) Systemic administration of MPEP dose-dependently inhibited reinstatement of drug-seeking behavior triggered by cocaine (H), but not by cues (I) or footshock stress (J). *p < 0.05, **p < 0.01, ***p < 0.001, compared to vehicle control group.

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