Figure 5 | Scientific Reports

Figure 5

From: Intact interleukin-10 receptor signaling protects from hippocampal damage elicited by experimental neurotropic virus infection of SJL mice

Figure 5

Targeted RT-qPCR based screening approach of pooled spleen samples of Theiler’s murine encephalomyelitis virus (TMEV)-infected SJL mice following IL-10R blockade at 7 days post infection. Fold changes of transcript levels of IL-10R-blocked animals in comparison to the isotype-treated group. Quantification of (a) cytokines/interferon-related genes, (b) chemokines/chemokine receptors and (c) genes related to innate immunity. Ifi16, Ccl2, Arg1 and Chi3l3 reached the 1.5 fold change threshold. For a detailed description of primer sequences and full gene names see Supplemental Table S2.

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