Figure 5

Biodistribution studies reveal different accumulation of [1-11C]dehydroascorbate (DHA) and [1-11C]vitamin C (VitC) in normal rat brain, but no effect of diethyl maleate (DEM) treatment. Gamma counting of harvested brains showed a significantly higher signal accumulation for [1-11C]DHA than [1-11C]VitC in the normal brain 1 hour following radiopharmaceutical administration. In addition, there was significantly higher uptake/retention for [1-11C]VitC versus [1-11C]DHA in the lungs and liver in normal rats. In the DEM-treated rats with [1-11C]DHA, no significant differences were found in 11C radiopharmaceutical uptake/retention between normal and DEM-treated rats in major organs, including the brain. (*p < 0.05, ***p < 0.001).