Table 1 Characteristics of participants according to the diagnostic probability of FH phenotype.

From: Familial hypercholesterolemia in very young myocardial infarction

 

All

Diagnostic probability of FH

Definite/probable

Possible

Unlikely

P for trend

Number

1093

71

374

648

 

Prevalence,%

100.0%

6.5%

34.2%

59.3%

 

Men,% (n)

96.8(1058)

97.2(69)

96.5(361)

96.9(628)

0.927

Age (year)

31.6 ± 3.6

31.0 ± 4.9

32.0 ± 3.3

31.5 ± 3.6

0.045

BMI (kg/m2)

27.26 ± 3.97

26.99 ± 3.35

27.95 ± 3.72

26.79 ± 4.19

0.079

Hypertension,% (n)

38.1 (416)

33.8 (24)

42.5 (159)

36.0 (233)

0.174

Diabetes mellitus,% (n)

17.1 (187)

19.7 (14)

18.2 (68)

16.2 (105)

0.779

Current smokers (%)

68.3 (746)

64.8 (46)

69.0 (258)

68.2 (442)

0.784

Family history of CAD,% (n)

21.7 (237)

39.4 (28)

55.9 (209)

0 (0)

<0.001

TG (mmol/L)

1.74 (1.24–2.41)

1.96 (1.62–2.53)

1.84 (1.27–2.51)

1.66 (1.20–2.31)

0.002

TC (mmol/L)

4.17 ± 1.30

6.44 ± 1.46

4.43 ± 1.28

3.77 ± 0.97

<0.001

HDL-C (mmol/L)

0.91 ± 0.25

0.90 ± 0.20

0.90 ± 0.23

0.91 ± 0.27

0.842

LDL-C (mmol/L)

2.53 ± 1.16

4.86 ± 1.53

2.76 ± 1.10

2.14 ± 0.73

<0.001

Untreated LDL-C (mmol/L)

3.17 ± 1.56

7.31 ± 1.55

3.44 ± 1.27

2.57 ± 0.79

<0.001

ApoAI (g/L)

1.14 ± 0.26

1.09 ± 0.26

1.14 ± 0.26

1.15 ± 0.26

0.201

ApoB(g/L)

0.95 ± 0.33

1.44 ± 0.34

1.03 ± 0.33

0.86 ± 0.26

<0.001

Lp (a) (mg/L)

136.65 (54.47–318.28)

261.30 (114.38–478.27)

142.78 (61.48–329.31)

122.46 (48.67–280.96)

<0.001

Glucose (mmol/L)

5.72 ± 2.26

6.23 ± 2.82

5.93 ± 2.25

5.54 ± 2.18

0.004

HbA1C (%)

6.14 ± 2.06

6.35 ± 1.62

6.15 ± 1.37

6.11 ± 2.41

0.615

Hs-CRP (mg/L)

2.41 (1.10–8.12)

3.99 (1.63–10.04)

2.66 (1.32–8.40)

2.16 (0.96–7.14)

0.006

Lipid-lowering treatment,% (n)

35.7 (390)

69.0 (49)

38.2 (143)

30.6 (198)

<0.001

VHR,% (n)

92.5 (1011)

98.6 (70)

95.7 (358)

90.0 (583)

<0.001

Gensini score

22 (4–48)

34 (16–66)

23 (4–50)

20 (2–46)

<0.001

  1. Data shown are mean ± SD, median (interquartile) or n (%). The bold values indicated statistical significance. FH, familial hypercholesterolemia; BMI, body mass index; CAD, coronary artery disease; TG, triglyceride; TC, total cholesterol; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; apo, apolipoprotein; Lp(a), Lipoprotein(a); HbA1C, hemoglobin A1C; Hs-CRP, high sensitively C reactive protein; VHR, very high risk.
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