Figure 8 | Scientific Reports

Figure 8

From: Expression of human mutant cyclin dependent kinase 4, Cyclin D and telomerase extends the life span but does not immortalize fibroblasts derived from loggerhead sea turtle (Caretta caretta)

Figure 8

Multiple alignments of CDK4 protein among humans, monkeys, bovines, pigs, and turtles. The amino acid sequences were obtained from the UCSC Genome Bioinformatics database (http://www.ucsc.edu). The conserved amino acids are highlighted with black boxes. The functional motifs corresponding to the ATP-binding ___domain (A) and substrate-binding ___domain (S) are marked on the sequences. The core amino acid for the binding to p16 protein (24 R) is highlighted with an asterisk.

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