Figure 7 | Scientific Reports

Figure 7

From: Death-associated protein kinase 1 mediates interleukin-1β production through regulating inlfammasome activation in Bv2 microglial cells and mice

Figure 7

Repeated DAPK1 inhibitor treatment ameliorates Aβ25–35-induced memory deficits. (A) Time chart of experimental procedure. (B) The recognition index during the retention memory phase in the ORT. (C) Total distances travelled in the open-field for 5 min were recorded. (D–E) Contextual- (D) and cue-fear conditioning (E) learning of mice, as presented by the percentage freezing time during the tests. Data are presented as mean ± SEM (n = 11). *P < 0.05, **P < 0.01; ##P < 0.01, ###P < 0.001. Context: contextual-conditioning fear test; Cue: cue-conditioning fear test; DI: DAPK1 inhibitor.

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