Figure 2
Invasion kinetics of P. knowlesi filter isolated merozoites. (a) Proportion of merozoites invading RBCs (invasion rate) is influenced by ratio of merozoites:RBCs. Data are representative of n = 7 assays in duplicate. (b) Merozoite:RBC ratio giving 50% maximum invasion rate (IR50). For each experiment the highest invasion rate was normalized to 100% (IRmax) and invasion rates at all other ratios expressed as a proportion of IRmax (n = 7 experiments shown). (c) Increasing the merozoite:RBC ratio leads to an increase in parasitemia (n = 7 assays in duplicate shown). (d) The proportion of merozoites that have invaded with increasing time shown as % of invasion after 45 mins (mean of n = 3 experiments in duplicate). Error bars of SEM are not visible as they are shorter than height of symbols.
