Figure 4
The uptake of glimepiride (A) and gliclazide (B) in OATP1B1*1a, *5, and *15-HEK293T cells using different substrate concentrations. Uptake of glimepiride and gliclazide in HEK293T cells was studied using concentrations from 2.5 to 80 μM. The uptake experiments were divided into four groups including MOCK-HEK293T cells group, OATP1B1*1a-HEK293T cells group, OATP1B1*5 -HEK293T cells group and OATP1B1*15-HEK293T cells group. Statistical analysis was conducted using SSPS19.0. **Statistically different, P < 0.01, n = 4).
