Figure 3 | Scientific Reports

Figure 3

From: Paraoxonase 1 knockout rats have impaired T cell development at the CD4/CD8 double-negative to double-positive transition stage

Figure 3

PON1-deficiency blocks T lymphocyte maturation at the DN stage. (a) Representative staining profiles for T cells and the percentages of double-negative (DN), CD4+, CD8+ and double-positive (DP) in the thymus of 2-month old PON1−/− and PON1+/+ rats. (b) Immunohistochemical analysis of CD4+, CD8+ cells in the cortex and medulla of the thymus of 2-month-old PON1−/− and PON1+/+ rats. Scale bar = 100 μm. (c) Representative staining profiles for DN cells and the percentage of DN1, DN2, DN3 and DN4 cells in the thymus from 2-month-old PON1−/− and PON1+/+ rats. Data represent the mean ± SD of three independent experiments. *P < 0.05; **P < 0.01.

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