Table 5 RPE test results for HLA-DRB1 and HLA-DQB1 alleles. Each allele in each gene is the result of association after removing all the significant alleles listed above. (222 IMN vs. 701 Controls).
HLA-DRB1 Alleles | IMN (2n = 428) | Control (2n = 1226) | OR | P | RPE | ||||
|---|---|---|---|---|---|---|---|---|---|
No. | % | No. | % | (95% CI) | OR (95% CI) | P | Pc | ||
DRB1*15:01 | 91 | 21.26% | 100 | 8.16% | 3.04 (2.24–4.15) | 2.80 × 10−13 | — | — | — |
DRB1*14:54 | 22 | 5.14% | 38 | 3.10% | 1.69 (0.99–2.9) | 0.0519 | 2.5 (1.43–4.37) | 0.00094 | 0.0188 |
DRB1*11:01 | 20 | 4.67% | 31 | 2.53% | 1.89 (1.07–3.35) | 0.027 | 2.61 (1.39–4.91) | 0.002 | 0.04 |
DRB1*14:05 | 20 | 4.67% | 25 | 2.04% | 2.35 (1.29–4.28) | 0.0039 | 2.49 (1.18–5.22) | 0.013 | ns |
HLA-DQB1 Alleles | IMN (2n = 427) | Control (2n = 1226) | OR | P | RPE | ||||
No. | % | No | % | (95% CI) | OR (95% CI) | P | Pc | ||
DQB1*06:02 | 84 | 19.67% | 96 | 7.83% | 2.88(2.1–3.96) | 1.33 × 10–11 | — | — | — |
DQB1*05:02 | 18 | 4.22% | 22 | 1.79% | 2.41 (1.28–4.54) | 0.0051 | 3.33 (1.69–6.57) | 0.00024 | 0.00288 |
DQB1*03:01 | 66 | 15.46% | 141 | 11.50% | 1.41 (1.03–1.93) | 0.0334 | 1.71 (1.19–2.46) | 0.0032 | 0.0352 |
DQB1*05:03 | 22 | 5.15% | 48 | 3.92% | 1.33 (0.79–2.24) | 0.27 | 1.83 (0.93–3.61) | 0.078 | ns |
