Figure 7
From: Activation Stoichiometry and Pore Architecture of TRPA1 Probed with Channel Concatemers
TRPA1 channels with 3 subunits harboring C622S mutation cannot be activated by cinnamaldehyde. (A) Response to 100 µM cinnamaldehyde of currents in cells transfected with 3 D918H - 1 WT and 3 C622S/D918H - 1 WT. Note that in (B), the current is spontaneously increasing and there is no correlation with the application of cinnamaldehyde. (C) Summary of current magnitudes measured before and after treatment of cinnamaldehyde. **P < 0.01 (Sidak’s multiple comparison following two-way ANOVA). (D) Summary of current magnitude changes during a 100 s window with or without cinnamaldehyde. n.s. P > 0.05 (repeated measures one-way ANOVA).
