Figure 4 | Scientific Reports

Figure 4

From: Glucose Activates Vagal Control of Hyperglycemia and Inflammation in Fasted Mice

Figure 4

Dopamine controls hyperglycemia in experimental sepsis. (ac) Fasted animals underwent (a) sham or (a,c) surgical adrenalectomy (ADX) 3 days before LPS. Then, animals underwent control or vagal stimulation (VS; 10 Hz, 15 min) right before the LPS challenge. (a) Blood glucose or (b,c) catecholamines (dopamine(DA), norepinephrine (NE) or epinephrine (E) were analyzed at 1.5 h post-LPS. (df) Fasted mice were treated with vehicle (control), dopamine (DA; 10 mg/kg/dose; i.p.) or fenoldopam (Fen; 10 mg/kg/dose; i.p.) at 6 and 1 h before the LPS challenge. (d,e) Blood glucose and (f) serum TNF levels were analyzed at the indicated time points. (g,h) All mice received streptozotocin (STZ; 40 mg/kg) and were treated with vehicle (control) or fenoldopam (Fen; 10 mg/kg/dose; i.p.) at 6 and 1 h before LPS. Blood glucose (g) and TNF (h) were analyzed at the indicated time points. (a,f) +p < 0.05 vs LPS (n = 4/group; One-way ANOVA); (b,c) #p < 0.05 vs LPS (n = 3/group; Student’s t-test); (d,e,g,h) *p < 0.05 vs control (n = 4/group, Two-way ANOVA).

Back to article page