Figure 7 | Scientific Reports

Figure 7

From: Ghrelin protects against contact dermatitis and psoriasiform skin inflammation by antagonizing TNF-α/NF-κB signaling pathways

Figure 7

Schematic depicting ghrelin’s proposed effect on contact dermatitis and psoriasis. TNF-α binds to TNFR, which activates IKK to phosphorylate and degrade IκBα. This change results in activation of the NF-κB signaling pathway, causing the secretion of proinflammatory cytokines and subsequent inflammation. Ghrelin exerts its effects through binding to GHSR1a, followed by antagonizing TNF-α, resulting in suppression of NF-κB signaling. This signaling pathway represents a potential therapeutic method for both contact dermatitis and psoriasis.

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