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Figure 1

From: Mianserin suppresses R-spondin 2-induced activation of Wnt/β-catenin signaling in chondrocytes and prevents cartilage degradation in a rat model of osteoarthritis

Figure 1

Rspo2 in synovial fluid of knee joints is increased in OA patients with Kellgren-Lawrence (KL) grades 2 and 3. (A–C) Concentrations of glycosaminoglycans (GAG) in synovial fluid were measured by a spectrophotometric dye binding assay using 1,2, dimethylmethylene blue (DMMB), and were plotted against the KL grading scale representing OA severity for females (n = 36) (A), males (n = 16) (B), and all patients (n = 52) (C). (D–F) The amount of Rspo2 was normalized to the amount of total protein in synovial fluid. Rspo2 in females (n = 36) (D), males (n = 16) (E), and all patients (n = 52) (F) are plotted against the KL grading scale. Bars indicate average values for each KL grade. *P < 0.05 and **P < 0.01 by one-way ANOVA followed by Tukey’s post-hoc test. Values of each patient are shown in Supplementary Table S1.

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