Figure 3
From: Palladium based nanoparticles for the treatment of advanced melanoma
Hyaluronic acid nanoparticles with Tris DBA-Pd reveal efficacy in vemurafenib-resistant melanoma. Nude male mice were inoculated with LM36R (5.0 × 105 cells), a human cell line of melanoma that is resistant to vemurafenib, and then treated with HANPs over the course of four weeks. When compared to the other groups, hyaluronic acid nanoparticles conjugated with Tris DBA-Pd (Tris DBA-Pd HANP) proved most effective. Interestingly, HANPs with Tris DB-Pd proved even more effective than free Tris DBA-Pd and HANPs with Tris DBA-Pd conjugated with an IGF1R antibody (n = 5 per group) (Asterisk indicates significance with a p-value of 0.048 at week 4).
