Figure 7
Actions of a NOX4 blocker in KGN. KGN treatment with GKT137831 resulted in a significant reduction in cell number (A; n = 6) and confluence (B; n = 4), as well as reduced PCNA content. The figure was cropped and the original gel images are shown in the supplementary data (C) PCNA in KGN compared to control (blotted membrane of one representative example is shown). Diagram shows PCNA levels of control versus treated cells normalized to β-actin (n = 4). (D) Treatment with GKT137831 had no cytotoxic effect in KGN compared to control (LDH cytotoxicity assay; n = 5). One-sample t-tests (two-tailed; *p < 0.05).
