Table 3 Biochemical Measurements at Baseline and during Follow-Up.

From: Carotid artery plaque intervention with Tongxinluo capsule (CAPITAL): A multicenter randomized double-blind parallel-group placebo-controlled study

 

Baseline

12 months

24 months

LS mean change from baseline to 12 months

LS mean change from baseline to 24 months

#Interaction P values

LDL-C (mg/dl)

Tongxinluo (N)

113.63 ± 32.96 (595)

115.05 ± 32.29 (487)

113.75 ± 31.23 (470)

0.659 (−1.921, 3.240)

−1.007 (−3.621, 1.607)

0.283

Placebo (N)

113.23 ± 32.23 (597)

116.16 ± 34.77 (492)

116.62 ± 33.86 (484)

1.911 (−0.669,4.492)

3.0781 (0.506, 5.651)

 

Difference

   

−1.252 (−4.902, 2.398)

−4.085 (−7.754, −0.417)

 

P values

   

0.501

0.029

 

TC (mg/dl)

Tongxinluo (N)

189.05 ± 43.11 (596)

190.82 ± 43.05 (488)

188.15 ± 38.52 (472)

1.475 (−1.743, 4.694)

−1.634 (−4.891, 1.622)

0.264

Placebo (N)

186.22 ± 39.75 (597)

193.25 ± 43.06 (496)

193.27 ± 41.01 (486)

5.701 (2.487, 8.912)

6.258 (3.053, 9.463)

 

Difference

   

−4.225 (−8.775, 0.325)

−7.892 (−12.465, −3.319)

 

P values

   

0.069

<0.001

 

TG (mg/dl)

Tongxinluo (N)

140.82 ± 78.72 (596)

143.56 ± 75.56 (489)

142.85 ± 78.09 (473)

1.899 (−2.787, 6.584)

−0.148 (−4.889, 4.593)

0.943

Placebo (N)

137.41 ± 81.69 (597)

146.27 ± 83.83 (496)

144.70 ± 85.74 (485)

9.014 (4.332, 13.696)

7.310 (2.634, 11.985)

 

Difference

   

−7.116 (−13.741, −0.490)

−7.458 (−14.118, −0.798)

 

P values

   

0.035

0.028

 

HDL-C (mg/dl)

Tongxinluo (N)

50.43 ± 13.75 (596)

51.17 ± 12.35 (486)

51.56 ± 12.40 (470)

0.644 (−0.295, 1.583)

1.273 (0.323, 2.223)

0.346

Placebo (N)

51.16 ± 12.89 (597)

50.58 ± 12.79 (492)

49.92 ± 13.45 (484)

−0.459 (−1.397, 0.480)

−0.734 (−1.669, 0.202)

 

Difference

   

1.102 (−0.226, 2.430)

2.007 (0.673, 3.340)

 

P values

   

0.104

0.003

 

hs-CRP (mg/l)

Tongxinluo (N)

2.03 ± 2.06 (458)

1.92 ± 2.35 (350)

2.04 ± 1.97 (337)

−0.095 (−0.317, 0.128)

−0.011 (−0.237, 0.215)

0.636

Placebo (N)

1.87 ± 2.03 (473)

1.97 ± 2.42 (371)

2.18 ± 2.42 (344)

0.045 (−0.172, 0.263)

0.236 (0.013, 0.459)

 

Difference

   

−0.140 (−0.452, 0.171)

−0.247 (−0.565, 0.070)

 

P values

   

0.378

0.127

 
  1. All continuous values were mean ± SD except fort changed outcome values from baseline to 12 or 24 months which were analyzed by linear mixed-effects model and expressed as least squares (LS) mean and 95% CI. #Interaction p value: the difference between the two groups induced by the interaction between treatment groups and time. LDL-C: low-density lipoprotein cholesterol; TC: total cholesterol; TG: triglycerides; HDL-C: high-density lipoprotein cholesterol; hs-CRP: high-sensitivity C-reactive protein. To convert values of LDL-C, TC and HDL-C to millimoles per liter, multiply by 0.0259. To convert values of TG to millimoles per liter, multiply by 0.0113.
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