Figure 3 | Scientific Reports

Figure 3

From: White matter microstructural abnormalities and default network degeneration are associated with early memory deficit in Alzheimer’s disease continuum

Figure 3

Severity-dependent associations of free water (FW), tissue compartment fractional anisotropy (FAT), grey matter volume (GMV), and functional connectivity (FC) with memory performance derived from a sparse varying coefficient model. Solid curves represent the mean associations (Beta coefficients) of brain measurements, with memory as a function of dementia severity (represented by the Clinical Dementia Rating Scale, sum-of-boxes (CDR-SB)) estimated from 100 replicates. The dashed curves represent the point-wise 2* standard errors of the solid curves estimated from 100 replicates. The horizontal dashed black lines represent Beta = 0. Abbreviations: HIP: hippocampus, PCC: posterior cingulate cortex, mPFC: medial prefrontal cortex.

Back to article page