Figure 1 | Scientific Reports

Figure 1

From: Preventing lung pathology and mortality in rabbit Staphylococcus aureus pneumonia models with cytotoxin-neutralizing monoclonal IgGs penetrating the epithelial lining fluid

Figure 1

Dose-dependent protection elicited by ASN100 in rabbit models of lethal pneumonia. (A) Rabbits were intravenously immunized with ASN100 (0.08 mg/kg to 20 mg/kg) or placebo (ASN100 formulation buffers) 24 hours before intra-tracheal challenge with S. aureus strains indicated. Survival was monitored for 168 hours post-challenge. Results of two independent experiments are shown (each with 3 rabbits/group, total n = 6). Kaplan-Meier plots show survival of animals including statistical analysis (log-rank, Mantel-Cox) indicated as P-values relative to the placebo control group. (B) Representative pictures of lungs from infected rabbits challenged with the USA300 CA-MRSA (LAC) strain that received ASN100 (20 mg/kg) or placebo 24 hours before. Pictures taken at time of death (18 hours; placebo) or at the end of the study (7 days; ASN100).

Back to article page