Figure 3 | Scientific Reports

Figure 3

From: Preventing lung pathology and mortality in rabbit Staphylococcus aureus pneumonia models with cytotoxin-neutralizing monoclonal IgGs penetrating the epithelial lining fluid

Figure 3

Effect of ASN100 on bacterial lung-burden and systemic dissemination. 24 hours prior to lethal challenge with the S. aureus LAC strain, rabbits were intravenously immunized with ASN100 (1.25, 5, or 20 mg/kg) or placebo. Bacterial organ loads were determined from lungs (A), spleens (B), left and right kidneys (C), by plating of homogenized organ samples harvested at 12 hours post challenge. Individual animals are represented by open and closed symbols for the two independent studies (each with 3 rabbits/group) and lines indicate the group mean values. P-values were calculated based on group-comparison by the Mann-Whitney test and are shown for all statistically different comparisons.

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