Figure 1
From: Maf deficiency in T cells dysregulates Treg - TH17 balance leading to spontaneous colitis
MafΔTcells mice develop late-onset spontaneous colitis. (A) Body weight curves of Maff/f (n = 8) and MafΔTcells (n = 6) male littermates. Statistical significances were calculated by a Bonferroni test after a significant two-way ANOVA. (B) Representative pictures of colons from Maff/f and MafΔTcells mice. (C) Haematoxylin and eosin-stained sections of colons (upper picture: scale bar 200 µm; bottom pictures: scale bar 100 µm) and (D) histological scores (from 0 to 6) of microscopic changes in the colon from Maff/f and MafΔTcells mice (n = 7 per group). (E) Total immune cell numbers in mLN (left) and colon (right) of Maff/f and MafΔTcells mice (n > 10 per group). (F) Absolute cell numbers of CD4+ and CD8+ T cells in colons of Maff/f and MafΔTcells mice (n > 10 per group). (D–F) Each symbol represents an individual mouse. (E,F) Data are representative of at least 2 independent experiments with at least 4 mice per group. All mice were over 20 weeks old. All graphs indicate means. Error bars display Standard Error Mean (SEM).
