Table 2 Statistics of satisfied conditions for Lipinski’s “rule of five” of molecules in the AICD and approved small drugs in DrugBank.
From: AICD: an integrated anti-inflammatory compounds database for drug discovery
Rule of five | DrugBank (2144) | AICD_all (79781) |
|---|---|---|
All satisfied | 1457 (68.0%) | 49888 (62.5%) |
Except MW | 1503 (70.1%) | 56159 (70.4%) |
Except hydrogen bond acceptors | 1489 (69.4%) | 50137 (62.8%) |
Except hydrogen bond donors | 1541 (71.9%) | 51985 (65.2%) |
Except AlogP | 1556 (72.6%) | 57562 (72.1%) |
