Figure 1
From: Functional characterisation of a novel class of in-frame insertion variants of KRAS and HRAS
Identification of RAS in-frame insertion variants. (A) Pie-chart showing potentially causative variants found in 299 diagnostic cases with VMOS. RAS: HRAS, KRAS or NRAS; others genes from panel, variation in one of the sequenced genes with exception of RAS genes; no gene from panel, no variation in any sequenced gene (details in Materials and Methods). (B) Pie-chart of the type of RAS variants found. White, classical mutations; grey in-frame insertions around amino acid position 65. K, KRAS; N, NRAS. Mutation on amino acid level. (C) Comparison of the RAS variants found in cases of VMOS with variants identified in 3234 oncology related diagnostic requests. Each box represents one codon. Grey boxes, codons covered by NGS analysis. The variants found in oncology related diagnostics and VMOS cases are indicated above and underneath of the affected codons, respectively. Each circle/item represents one case.
