Figure 2 | Scientific Reports

Figure 2

From: High-throughput sequencing of IgG B-cell receptors reveals frequent usage of the rearranged IGHV4–28/IGHJ4 gene in primary immune thrombocytopenia

Figure 2

IGHV repertoires and diversity in primary ITP. (A) Characteristic IGHV repertoires of IgG BCRs in primary ITP were an increased usage of the IGHV4–28 segment and a decreased usage of the IGHV3–15 segment. (B) Diversity indices of Simpson and Pielou were not statistically different between the two groups (p = 0.303 and 0.095, respectively). The Shannon scores were slightly higher in ITP patients (p = 0.031). The total numbers of in-frame reads in ITP and control were 885,793 and 1,124,150, respectively, and the total unique reads in ITP and control were 215,640 and 99,829, respectively. Thus, the richness in B-cell clones was even higher in the ITP group than the control group of this cohort.

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