Figure 1
From: Elevated numbers of PD-L1 expressing B cells are associated with the development of AIDS-NHL
Bregs were elevated prior to AIDS-NHL. (A) Multi-color flow cytometry for Breg cell phenotype (CD19+CD24++CD38++) was performed on prospectively collected PBMC from AIDS-NHL cases and matched HIV+ and HIV-negative controls. Breg cells were gated as CD19+CD24++CD38++; absolute numbers of Breg cells (cells/mm3) were measured 1–4 years and >4 years prior to AIDS-NHL diagnosis. Lines in represent means. (B,C) Absolute numbers of Breg cells in PBMC from HIV+ controls are shown at the two different visits; lines represent each individual changes across visits; lines represent each individual changes across visits. p-values were calculated using either an F-test or t-test for the difference in log means in a linear mixed model, respectively.
