Table 5 Cumulative effects of combined risk alleles (rs7101916 T and rs28372683 A) on the susceptibility to HCV infection.

From: Genetic mutations in NF-κB pathway genes were associated with the protection from hepatitis C virus infection among Chinese Han population

Variables

Group A

Group (B + C)

Group (B + C)/Group A

n

n

OR(95% CI)a

P a

0

302

277

1

 

1

439

296

0.702 (0.554–0.890)

0.003

2

189

94

0.543 (0.396–0.747)

1.68e-4

3

31

8

0.254 (0.111–0.580)

0.001

4

1

4

3.974 (0.403–39.226)

0.237

Trend

   

8e-6 b

1–4

660

402

0.641 (0.514–0.799)

7.9e-5

  1. Abbreviations: HCV, hepatitis C virus; OR, odds ratio; 95% CI, 95% confidence interval.Group A: controls; Group B: spontaneous clearance subjects; Group C: persistent infection patients. Group (B+C): HCV-infected individuals. aLogistic regression model, adjusted for gender, age and routes of infection. bCochran–Armitage trend test. Bold type indicates statistically significant results.
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