Figure 4

Gene arrangement within the dg region of strains with the multi-cagA genotype. All the strains carrying multiple copies of cagA harbored the type-B dg. Genes are drawn with filled arrows and DNA homology across the strain types is indicated by the same color. For comparison, the cagA copy number in strain J166, B125A, B128, 7.13, B130A, B140 and B147 is drawn as two copies. The first CHA-ud sequence upstream of cagA appears to have arisen from part of a AAA family ATPase gene. In strain B147, a ~39 kb insertion existed between CV730_03420 and CV730_03570. This insertion was delimited by two integrase genes indicated by empty arrows. The cagPAI region and CHA-ud are indicated.