Figure 3
Modulation of p43 signaling delays muscle regeneration. (A) Experimental setup. Tibialis muscle were injured by a single CTX injection and analyzed at different times following injury. (B) Assessment of muscle recovery evaluated by the ratio between the injected and contralateral tibialis weight analyzed at different times following injury (n = 6 for each group). (C) Anti-Laminin staining on cryosections of regenerated Tibialis muscles in wild-type, p43−/− and p43-Tg mice at 70 d.p.i. (D) Total fibers number in wild-type, p43−/− and p43-Tg mice at 70 d.p.i. (n = 6 for each group). (E) Mean fibers area in wild-type, p43−/− and p43-Tg mice at 70 d.p.i. (n = 6 for each group). (F) Fiber size distribution in wild-type and p43−/− mice at 70 d.p.i. (n = 6 for each group). (G) Fiber size distribution in wild-type and p43-Tg mice at 70 d.p.i. (n = 6 for each group). Statistical significance: *p < 0.05; ***p < 0.001. Student’s t-test. Results are expressed as ± sem.
