Figure 3 | Scientific Reports

Figure 3

From: Clinical, pathophysiologic, and genomic analysis of the outcomes of primary head and neck malignancy after pulmonary metastasectomy

Figure 3

Process and results of whole-exome sequencing. (a) After excluding unqualified HNSCC samples, a total of six matched pulmonary metastatic HNSCC samples (three short-term PMS HNSCC and three long-term PMS HNSCC) were sent for whole-exome sequencing. A total of 1,456 alternative genes fulfilled our criteria. These alterative genes were classified into short-term PMS HNSCC only (N = 430), long-term PMS HNSCC only (N = 420), or the intersection between short- and long-term PMS HNSCC (N = 606). Short- or long-term PMS only genes intersected with the identified genes from matched pulmonary metastatic samples of adenoid cystic carcinoma (ACC) (N = 1060). The similar genes of short- or long-term PMS HNSCC and ACC (N = 181, 185, respectively) might indicate cancer metastasis. (b) The heatmap of the alternative genes mapped in DAVID. The variant numbers of each gene are represented from white to red (variant numbers to color key, 0 to 0, 1 to 1, 2–3 to 2, 4–10 to 3, 11–25 to 4, > 25 to 5).

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