Figure 2 | Scientific Reports

Figure 2

From: Staphylococcal enterotoxins modulate the effector CD4+ T cell response by reshaping the gene expression profile in adults with atopic dermatitis

Figure 2

Impaired T cell cytokine secretion induced by SEA in AD. (a) Representative gating strategy for selection of CD3+CD4+ T cell population. Each subsequent panel shows only the population of interest producing each studied cytokine after SEA stimulation. (b) Frequencies of CD4+ T cells individually stained for IFN-γ, IL-17A, IL-22, MIP-1β or TNF after SEA stimulation from HC (n = 10) and AD patients (n = 15). Lines represent median with interquartile range. *p < 0.05, **p < 0.01, ***p < 0.001. (c) PCA of the CD4+ T cells polyfunctional profile. Boolean gating was used to calculate the proportions of polyfunctional T cells after SEA stimulation and frequency values were considered for analysis. Each dot represents one subject. PC, principal component.

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