Figure 2
From: SLE Plasma Profiling Identifies Unique Signatures of Lupus Nephritis and Discoid Lupus
Protein signatures associated with lupus nephritis (LN). (a) Area under the curve (AUC) of biomarkers between patients with LN and patients with systemic lupus erythematosus (SLE) without renal activity. (b) Correlation matrices displaying correlations in all patients with SLE between markers associated with LN and across traditional SLE biomarkers measured in SLE. Data clustered using 1-(Spearman’s R)2 as distance measure and complete linkage as clustering method. (c) Heatmap displaying patterns of prevalence of tumour necrosis factor receptor 2 (TNFR2), interleukin (IL)-1β, and fibrinogen across all patients with SLE. Samples ordered by weight sum of TNFR2, IL-1β, and fibrinogen. Heatmap colours represent measurements from SLE samples that were standardised to healthy donor (HD) measurements for each respective biomarker. Red colour bars (top) represent the presence or absence of different renal pathologies or severity of renal Lupus Activity Index (LAI) score. SLEDAI = SLE Disease Activity Index.
