Figure 6
From: SLE Plasma Profiling Identifies Unique Signatures of Lupus Nephritis and Discoid Lupus

Association between protein signatures, composite disease activity, and individual systemic lupus erythematosus (SLE) pathologies. (a) Spearman’s rank correlation of signature proteins with SLE Disease Activity Index (SLEDAI) excluding C3 and DNA binding (modified SLEDAI). Dotted lines represent Spearman’s R critical values needed to achieve statistical significance with α = 0.05. (b) Observed P values versus expected P values from Spearman’s rank correlation test of each analyte versus modified SLEDAI score. Dotted line represents expected minimum P value due to random chance. (c) Area under the curve (AUC) of antibody and protein measurements associated with lupus nephritis (LN) and discoid lupus (DL) between all patients with SLE and healthy donors (HD) and between patients with SLE presenting with different manifestations. ACL = acute cutaneous lupus; CL = cutaneous lupus; Ig = immunoglobulin; IL = interleukin; SS = Sjögren’s syndrome.