Figure 3
Effect of Ivabradine on the BRV of hESC and hiPSC. (A–D) Beating frequency, SDNN, SDSD and CV figured as mean ± SEM. Ivabradine decreased the beating frequency and increased BRV parameters dose-dependently. The results presented for 10−4 M include measurements that had to be stopped before the full recording time of eight minutes. Measurements performed on seven hESC derived EBs (n = 7) and six hiPSC derived EBs (n = 6) were included in the analysis. Each EB was measured once. *p ≤ 0.05.
