Table 2 Summary of findings: SGYMT compared with antidepressants.
Outcomes | No. participants (RCTs) | Anticipated absolute effects (95% CI) | Quality of evidence (GRADE) | Comments | ||
|---|---|---|---|---|---|---|
Risk with antidepressants | Risk with SGYMT | |||||
HAMD | Total | 560 (8) | — | MD 2.08 lower (2.62 to 1.53 lower) | ⊕⊕◯◯ LOW | Risk of bias (−1) Imprecision (−1) |
Subgroup 1 | ≤4 wk | 238 (3) | — | MD 1.98 lower (3.13 to 0.83 lower) | ⊕⊕◯◯ LOW | Risk of bias (−1) Imprecision (−1) |
>4 wk, ≤8 wk | 198 (3) | — | MD 2.48 lower (3.04 to 1.93 lower) | ⊕⊕⊕◯ MODERATE | Risk of bias (−1) | |
>8 wk | 124 (2) | — | MD 0.66 lower (2.11 lower to 0.78 higher) | ⊕⊕◯◯ LOW | Risk of bias (−1) Imprecision (−1) | |
Subgroup 2 | decoction | 480 (7) | — | MD 1.97 lower (2.51 to 1.42 lower) | ⊕⊕◯◯ LOW | Risk of bias (−1) Imprecision (−1) |
granule | 80 (1) | — | MD 3.26 lower (4.78 to 1.74 lower) | ⊕⊕◯◯ LOW | Risk of bias (−1) Imprecision (−1) | |
Subgroup 3 | SSRI | 342 (5) | — | MD 1.62 lower (2.38 to 0.86 lower) | ⊕⊕◯◯ LOW | Risk of bias (−1) Imprecision (−1) |
Flupentixol/melitracen | 218 (3) | — | MD 2.54 lower (3.12 to 1.96 lower) | ⊕⊕⊕◯ MODERATE | Risk of bias (−1) | |
TER (depression scale) | Total | 922 (11) | 802 per 1,000 | 890 per 1,000 (850 to 939) | ⊕◯◯◯ VERY LOW | Risk of bias (−1) Indirectness (−1) Imprecision (−1) |
Subgroup 1 | ≤4 wk | 612 (6) | 823 per 1,000 | 913 per 1,000 (856 to 971) | ⊕⊕◯◯ LOW | Risk of bias (−1) Indirectness (−1) |
>4 wk, ≤8 wk | 138 (2) | 729 per 1,000 | 882 per 1,000 (772 to 1,000) | ⊕⊕◯◯ LOW | Risk of bias (−1) Indirectness (−1) | |
>8 wk | 172 (3) | 791 per 1,000 | 830 per 1,000 (720 to 957) | ⊕◯◯◯ VERY LOW | Risk of bias (−1) Indirectness (−1) Imprecision (−2) | |
Subgroup 2 | decoction | 708 (9) | 782 per 1,000 | 892 per 1,000 (837 to 947) | ⊕◯◯◯ VERY LOW | Risk of bias (−1) Indirectness (−1) Imprecision (−1) |
granule | 214 (2) | 868 per 1,000 | 929 per 1,000 (833 to 1,000) | ⊕⊕◯◯ LOW | Risk of bias (−1) Indirectness (−1) | |
Subgroup 3 | SSRI | 464 (6) | 801 per 1,000 | 849 per 1,000 (785 to 905) | ⊕◯◯◯ VERY LOW | Risk of bias (−1) Indirectness (−1) Imprecision (−1) |
TCA | 300 (3) | 799 per 1,000 | 934 per 1,000 (839 to 1,000) | ⊕⊕◯◯ LOW | Risk of bias (−1) Indirectness (−1) | |
Flupentixol/melitracen | 158 (2) | 813 per 1,000 | 951 per 1,000 (845 to 1,000) | ⊕⊕◯◯ LOW | Risk of bias (−1) Indirectness (−1) | |
TER (stroke scale) | Total (SSRI) | 258 (3) | 680 per 1,000 | 890 per 1,000 (782 to 1,000) | ⊕⊕◯◯ LOW | Risk of bias (−1) Indirectness (−1) |
Subgroup 1 | ≤4 wk | 134 (1) | 864 per 1,000 | 915 per 1,000 (812 to 1,000) | ⊕⊕◯◯ LOW | Risk of bias (−1) Indirectness (−1) |
>8 wk | 124 (2) | 484 per 1,000 | 871 per 1,000 (663 to 1,000) | ⊕◯◯◯ VERY LOW | Risk of bias (−1) Indirectness (−1) Imprecision (−1) | |
Subgroup 2 | decoction | 124 (2) | 484 per 1,000 | 871 per 1,000 (663 to 1,000) | ⊕◯◯◯ VERY LOW | Risk of bias (−1) Indirectness (−1) Imprecision (−1) |
granule | 134 (1) | 864 per 1,000 | 915 per 1,000 (812 to 1,000) | ⊕⊕◯◯ LOW | Risk of bias (−1) Indirectness (−1) | |
NIHSS | Total (decoction) | 138 (2) | — | MD 0.84 lower (1.40 to 0.29 lower) | ⊕⊕◯◯ LOW | Risk of bias (−1) Imprecision (−1) |
Subgroup 1 | ≤4 wk | 60 (1) | — | MD 0.37 lower (1.37 lower to 0.63 higher) | ⊕◯◯◯ VERY LOW | Risk of bias (−1) Imprecision (−2) |
>4 wk, ≤8 wk | 78 (1) | — | MD 1.05 lower (1.71 to 0.39 lower) | ⊕⊕◯◯ LOW | Risk of bias (−1) Imprecision (−1) | |
Subgroup 2 | SSRI | 60 (1) | — | MD 0.37 lower (1.37 lower to 0.63 higher) | ⊕◯◯◯ VERY LOW | Risk of bias (−1) Imprecision (−2) |
Flupentixol/melitracen | 78 (1) | — | MD 1.05 lower (1.71 to 0.39 lower) | ⊕⊕◯◯ LOW | Risk of bias (−1) Imprecision (−1) | |
CSS | Total (decoction/SSRI) | 184 (3) | — | MD 5.37 lower (6.60 to 4.15 lower) | ⊕⊕⊕◯ MODERATE | Risk of bias (−1) |
Subgroup 1 | >4 wk, ≤8 wk | 60 (1) | — | MD 4.20 lower (5.95 to 2.45 lower) | ⊕⊕◯◯ LOW | Risk of bias (−1) Imprecision (−1) |
>8 wk | 124 (2) | — | MD 6.50 lower (8.21 to 4.79 lower) | ⊕⊕⊕◯ MODERATE | Risk of bias (−1) | |
Barthel index | Total (SSRI) | 234 (3) | — | MD 4.30 higher (2.04 to 6.57 higher) | ⊕⊕◯◯ LOW | Risk of bias (−1) Imprecision (−1) |
Subgroup 1 | ≤4 wk | 194 (2) | — | MD 3.16 higher (0.63 to 5.68 higher) | ⊕⊕◯◯ LOW | Risk of bias (−1) Imprecision (−1) |
>8 wk | 40 (1) | — | MD 8.99 higher (3.88 to 14.10 higher) | ⊕⊕◯◯ LOW | Risk of bias (−1) Imprecision (−1) | |
Subgroup 2 | decoction | 100 (2) | — | MD 4.20 higher (0.89 to 7.52 higher) | ⊕◯◯◯ VERY LOW | Risk of bias (−1) Imprecision (−2) |
granule | 134 (1) | — | MD 4.39 higher (1.29 to 7.49 higher) | ⊕⊕⊕◯ MODERATE | Risk of bias (−1) | |
AEs | Total | 416 (6) | 196 per 1,000 | 26 per 1,000 (10 to 73) | ⊕◯◯◯ VERY LOW | Risk of bias (−1) Imprecision (−2) |
Subgroup 1 | ≤4 wk | 178 (2) | 112 per 1,000 | 11 per 1,000 (1 to 83) | ⊕◯◯◯ VERY LOW | Risk of bias (−1) Imprecision (−2) |
>4 wk, ≤8 wk | 198 (3) | 240 per 1,000 | 12 per 1,000 (2 to 79) | ⊕◯◯◯ VERY LOW | Risk of bias (−1) Imprecision (−2) | |
>8 wk | 40 (1) | 350 per 1,000 | 102 per 1,000 (25 to 424) | ⊕⊕◯◯ LOW | Risk of bias (−1) Imprecision (−1) | |
Subgroup 2 | decoction | 336 (5) | 201 per 1,000 | 30 per 1,000 (10 to 89) | ⊕◯◯◯ VERY LOW | Risk of bias (−1) Imprecision (−2) |
granule | 80 (1) | 175 per 1,000 | 12 per 1,000 (0 to 198) | ⊕⊕◯◯ LOW | Risk of bias (−1) Imprecision (−1) | |
Subgroup 3 | SSRI | 198 (3) | 283 per 1,000 | 40 per 1,000 (8 to 184) | ⊕◯◯◯ VERY LOW | Risk of bias (−1) Imprecision (−2) |
Flupentixol/melitracen | 218 (3) | 118 per 1,000 | 8 per 1,000 (1 to 63) | ⊕◯◯◯ VERY LOW | Risk of bias (−1) Imprecision (−2) | |
