Figure 2
Phenotypic characterization of patient bearing novel variant in the ITGAM1 locus. Sera from healthy control donors and patients with SLE, including the individual bearing the novel mutation in the ITGAM1 locus (highlighted in red and indicated with red arrows) was assayed for IL-10 (A), MIF (B) and IL-37 (C) No healthy control donor data was available for MIF levels but this data has previously been published26. (D) Effector memory CD8 T cells in peripheral blood of healthy control donors and patients with SLE, and (E) the ratio of total CD4 to CD8 T cells in PBMC. Proportions of classical monocytes (F), plasmacytoid dendritic cells (pDC, G) and inflammatory monocytes (H) in PBMC. Bars show mean +/−standard deviation. For (A–C), n = 114, 159 and 127 respectively. For (E–H), n = 32 SLE patients and 16 HC.
