Figure 1 | Scientific Reports

Figure 1

From: A unique olfactory bulb microcircuit driven by neurons expressing the precursor to glucagon-like peptide 1

Figure 1

Preproglucagon (PPG) neurons express glutamatergic markers in the granule cell layer (GCL) of the olfactory bulb. (a) Left, representative photomicrograph of the GCL and mitral cell layer (MCL) in PPG-Cre-RFP transgenic mice transfected with AAV5 expressing ChR2-YFP conditional transgene (AAV5-Floxed-EYFP). Middle, same image (Merge) with DAPI nuclear stain. Right, enlarged magnification, inset delineated by the dashed box on left. (b) Representative photomicrographs of the glutamate transporter vGLUT2 visualized by immunocytochemistry in the external plexiform layer (EPL) of PPG-Cre-RFP transgenic mice. Arrow heads = co-expression of RFP (red channel; left) and vGLUT2 (green channel; middle) in synaptic terminals of PPG neurons in the EPL (merge; right).

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