Figure 4 | Scientific Reports

Figure 4

From: Comparing modes of delivery of a combination of ion channel inhibitors for limiting secondary degeneration following partial optic nerve transection

Figure 4

Effect of ion channel inhibitor combinations on node/paranode complexes. Paranode length (A), paranodal gap length (B), and percentage of atypical node/paranode complexes (C) from at least thirty nodal complexes per animal in the ventral optic nerve from uninjured normal; sham injured, local vehicle treated animals; injured, systemic and local vehicle treated animals; and systemic and local ion channel inhibitor treated animals 3 days after partial optic nerve transection. Graphs display min to max values, with the central line representing the median data point; N = 8–10 rats per group. Significant differences indicated by *p ≤ 0.05, **p ≤ 0.01, and ***p ≤ 0.001. (D) Representative image of two Caspr +areas flanking a β-III tubulin+ area or a typical nodal complex; scale bar = 2 µm. (E) Representative image of one Caspr+ area flanking a β-III tubulin+ area denoting an atypical nodal complex or a heminode; scale bars = 5 µm.

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