Figure 6 | Scientific Reports

Figure 6

From: Targeting ERβ in Macrophage Reduces Crown-like Structures in Adipose Tissue by Inhibiting Osteopontin and HIF-1α

Figure 6

Downregulation of OPN expression in macrophages in CLS by LY3201 treatment. (A–D) OPN fluorescent staining in SAT and VAT. Macrophages in CLS of vehicle-treated mice expressed high level of OPN both in SAT and VAT(A,B). OPN staining was much weaker in macrophages in CLS of mice treated by LY3201(C,D). (E,F) Expression of OPN was downregulated about 60% by LY3201 (*P < 0.01). (Scale bars in A-D, 50 μm).

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