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Figure 3

From: Genetic Characteristics of Korean Patients with Autosomal Dominant Polycystic Kidney Disease by Targeted Exome Sequencing

Figure 3

Renal outcomes and death according to type of PKD1/2 mutation. (A) Survival analysis of ESRD progression. (B) Survival analysis of all-cause mortality. The median age of ESRD was 63.5 for PKD1-PT genotype, followed by 68.8 for PKD1-NT and 72.9 for PKD2. When PKD1-PT genotype was used as a reference, the PKD2 genotype showed a 0.22 times lower HR of ESRD. The familial clustering effect was significant (P = 0.037). The incidence of death did not have difference according to genotypes. Abbreviations. ESRD, end-stage renal disease; PKD1-PT, PKD1 protein-truncating; PKD1-NT, PKD1 non-truncating; PKD1-ID, PKD1 small in-frameshift indels; HR, hazard ratio; CI, confidence interval.

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