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Figure 2

From: Humoral Immunogenicity and Efficacy of a Single Dose of ChAdOx1 MERS Vaccine Candidate in Dromedary Camels

Figure 2

Antibody responses in dromedaries vaccinated with ChAdOx1 MERS. (A) Seronegative calves were either immunised with control injections (PBS or ChAdOx1 eGFP) in group −C (open bars), or with ChAdOx1 MERS in group −V (green bars). Two calves in group −V were boosted with a second dose of ChAdOx1 MERS at 45 d.p.i. Data in green bars prior to 84 d.p.i. are from the two boosted calves only; and data after 84 d.p.i. (after infection challenge) are from all five calves. (B) Seropositive camels were either immunised with control injections (PBS or ChAdOx1 eGFP) in group +C (open bars) or with ChAdOx1 MERS in group +V (red bars). Serum samples from different days (d.p.i. and d.p.b.) were evaluated for anti-S1 Ab endpoint titres. Infectious camels used as a natural challenge model (from 84 d.p.i.) were also evaluated (black bars) in (A,B). (C) The fold increase in Ab titres of groups +C and +V. (D) Analysis of nAbs in samples collected from 0, 28 and 365 d.p.i. (in A,B) using MERSpp NA. ns: No significant difference in antibody titres at day 0 in +C versus +V camels, by Kruskal-Wallis test with Dunn’s Multiple comparison test. +: Seropositive; −: seronegative; C: control group; V: vaccinated group. d.p.i.: days post immunisation. d.p.b.: days post boost.

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