Figure 2
From: Differences in lipidome and metabolome organization of prefrontal cortex among human populations
Lipidome and metabolome population-specific differences in the DS:0-4 and DS:5-71 datasets. (A,B) Number of lipids (A) and metabolites (B) with significant abundance differences between one population and the other two combined, estimated by subsampling n individuals from each of the three populations 100 times. The numbers of subsampled individuals n used in analysis are marked on top of the panels. The results are shown for DS:5-71 (left, n = 25), DS:5-71 with same number n as DS:0-4 (middle, n = 13), and DS:0-4 (right, n = 13). The colors represent populations: red – Han Chinese (HC), green – Western Europeans (WE), blue – African Americans (AA). (C,D) The mean Area Under the ROC Curve (AUC) estimates for the lasso logistic regression models separating samples from one population and samples from the other two combined calculated using different values of hyperparameter C (inverse of regularization strength). The models were based on the lipid (C) and metabolite (D) abundance in DS:5-71 samples. Lines correspond to the means of AUC values estimated on different test sets. The shaded areas indicate the standard deviations of AUC values estimated on different test sets. The colors correspond to populations, as described above.
