Figure 2

Aged Plcg1^F/F; Dlx5/6-Cre mice show epileptic EEG patterns. (a) Schematic diagram of the EEG experimental procedure. (b) Representative recording traces of normal EEG patterns in control mice (left, 30 s) and temporal expansion of the same recording trace in dotted square (right, 6 s). (c) Representative traces of abnormal EEG patterns in freely moving Plcg1^F/F; Dlx5/6-Cre mice without handling stimulus (left, 30 s) and temporal expansion of the same recording trace in dotted square (right, 6 s). (d) Typical epileptic EEG activity in Plcg1^F/F; Dlx5/6-Cre mice (left, 5 min) and temporal expansion of the same recording trace in dotted square (right, 6 s). (e) EEG band power during awake state for 1 hour in non-behavioral seizure epochs without handling stimulus (control, n = 4; Plcg1^F/F; Dlx5/6-Cre, n = 6; two-way repeated measures ANOVA, genotype effect, *P = 0.0169, **P = 0.0054 in Sidak’s multiple comparison test). All data were expressed as mean ± SEM.