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Figure 2

From: Concurrent administration of IFNα14 and cART in TKO-BLT mice enhances suppression of HIV-1 viremia but does not eliminate the latent reservoir

Figure 2

HIV-1 viremia and viral recrudesce in cART or cART plus IFNα14 treated mice after 2 weeks of treatment withdrawal. (A) Schematic drawing of the experimental timeline. Mice were inoculated i.p with 1 × 104 TCIUs of HIV-1JR-CSF and infection was allowed to progress for 6 weeks. At 6wpi mice were either free-fed with cART chow, given cART chow plus daily i.p. injections of IFNα14 or left untreated for 4 weeks. At 10wpi all treatment was discontinued (analytical treatment interruption) for additional 2 weeks prior to sample collection at 12wpi. (B) Levels of HIV-1 viral RNA in plasma (untreated n = 9, ART n = 9, ART + IFNα14 n = 9) and (C) levels of total HIV-1 viral DNA and (D) levels of integrated proviral HIV-1 DNA in CD4+ enriched splenocytes (untreated n = 9, ART n = 9, ART + IFNα14 n = 10) were analysed. Box and whisker plots depict means with standard deviations and ranges. One-way ANOVA with Tukey’s post-test; ns = not significant. N = numbers of mice investigated.

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