Figure 1

Pedigree and sample information of family 1. Family 1 is a four generation family with approximately 40% individuals affected with asthma and atopy. Samples collected are marked with * symbol. Black square/circle denotes affected members while clear square/circle denotes unaffected subjects. No clear inheritance pattern could be identified from the pedigree. Interestingly, this family also has cases of consanguinity (depicted by double-lines=). Eight subjects- II:5, III:7, III:9, III:10, IV:31, IV:34, V:27, V:42 (five cases and three controls) were selected for Exome Sequencing.