Figure 3

Re-assorted ‘therapeutic genome’ of a hypothetical disease (d₁). The 20,000 protein coding genes are organised into 100 causal and 19,900 non-causal genes. Causal genes are further subdivided into 20 that are also druggable and 80 that are not. Of the 20 causal, druggable genes, 3 are the targets of licensed drugs for the treatment of d₁. Of the non-causal genes, 3980 are druggable but not causal for d₁. The right hand panel indicates the expected number of true and false positive genes (including druggable genes) expected in a GWAS of d₁ undertaken with a sample size that provides power, 1 − β = 0.8 and type 1 error rate of α = 5 × 10⁻⁸ at all loci.