Figure 1

Fundus and retinal thickness comparison between non-Ngb treated and Ngb treated retinae. (A) Fundus images after the Intravitreal injection of Ngb showing no evidence of inflammation, vasculitis or endophthalmitis. (B) Optical Coherence Topography after Intravitreal injection of Ngb showing no significant retinal thinning. (C) Annexin V immunohistochemistry using diaminobenzidine showing no increased apoptosis post intravitreal Ngb injection (performed in the presence of satisfactory positive controls, data not shown). (D) Morphometric analysis of individual retinal layers showing no statistical significance between the Ngb injected retinae and that of the sham controls. (RNFL: Retinal Nerve Fiber Layer, GCL: Ganglion Cell Layer, IPL: Inner Plexiform Layer, INL: Inner Nuclear Layer, OPL: Outer Plexiform Layer, ONL: Outer Nuclear Layer, PR: Photoreceptor Layer). Statistical Analysis: Simple T-Test, p < 0.05 taken as statistical significance. The values are in means ± SD.