Table 3 The univariate and multivariate survival analyses of GC patients in the whole study series.
Characteristics | n | 5-year OS (%) | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|---|---|
HR(95%CI) | P | HR(95%CI) | P | |||
Gender | ||||||
Male | 280 | 45.0 | 1 (ref) | |||
Female | 114 | 48.2 | 0.926 (0.694–1.236) | 0.604 | ||
Age (yr) | ||||||
<70 | 301 | 49.8 | 1 (ref) | 1 (ref) | ||
≥70 | 93 | 33.3 | 1.413 (1.058–1.888) | 0.019 | 1.408 (1.025–1.933) | 0.035 |
Tumor ___location | ||||||
Lower one-third | 112 | 56.3 | 1 (ref) | 1 (ref) | ||
Middle one-third | 231 | 42.9 | 1.509 (1.106–2.060) | 0.009 | 1.045 (0.740–1.447) | 0.802 |
2/3 or more | 51 | 37.3 | 1.485 (0.960–2.297) | 0.076 | 1.168 (0.918–1.314) | 0.056 |
Tumor diameter | ||||||
<5 cm | 142 | 57.0 | 1 (ref) | 1 (ref) | ||
≥5 cm | 252 | 39.7 | 1.666 (1.255–2.213) | <0.001 | 1.034 (0.752–1.421) | 0.838 |
Borrmann type | ||||||
I | 33 | 78.8 | 1 (ref) | 1 (ref) | ||
II | 121 | 49.6 | 2.630 (1.311–5.277) | 0.007 | 2.342 (1.141–4.805) | 0.020 |
III | 218 | 41.3 | 3.336 (1.697–6.557) | <0.001 | 2.589 (1.282–5.231) | 0.008 |
IV | 22 | 22.7 | 5.202 (2.310–11.714) | <0.001 | 4.176 (1.679–10.389) | 0.002 |
Histology | ||||||
Differentiated | 98 | 49.0 | 1 (ref) | |||
Undifferentiated | 296 | 44.9 | 1.048 (0.777–1.413) | 0.760 | ||
TNM stage | ||||||
II | 125 | 70.4 | 1 (ref) | 1 (ref) | ||
IIIa | 157 | 44.6 | 1.967 (1.387–2.791) | <0.001 | 1.707 (1.167–2.497) | 0.006 |
IIIb | 78 | 24.4 | 3.451 (2.359–5.050) | <0.001 | 3.685 (2.447–5.550) | <0.001 |
IIIc | 34 | 11.8 | 6.321 (3.978–10.042) | <0.001 | 5.112 (2.984–8.759) | <0.001 |
Type of gastrectomy | ||||||
Subtotal | 229 | 50.7 | 1 (ref) | 1 (ref) | ||
Total | 165 | 39.4 | 1.419 (1.095–1.838) | 0.008 | 1.702 (1.226–2.363) | 0.002 |
Extent of lymphadenectomy | ||||||
D2 | 262 | 41.2 | 1 (ref) | 1 (ref) | ||
D2 plus | 132 | 55.3 | 0.674 (0.507–0.897) | 0.007 | 0.658 (0.476–0.909) | 0.011 |
Total number of lymph node retrieval | ||||||
≥25 | 179 | 52.0 | 1 (ref) | 1 (ref) | ||
<25 | 215 | 40.9 | 1.372 (1.053–1.787) | 0.019 | 1.504 (1.092–2.072) | 0.012 |
Extranodal tumor deposits | ||||||
Absent | 281 | 52.7 | 1 (ref) | 1 (ref) | ||
Present | 113 | 29.2 | 2.110 (1.614–2.758) | <0.001 | 1.605 (1.200–2.147) | 0.001 |
Postoperative chemotherapy | ||||||
Yes | 296 | 48.6 | 1 (ref) | |||
No | 98 | 37.8 | 1.221 (0.913–1.631) | 0.178 | ||
