Figure 4 | Scientific Reports

Figure 4

From: Quantitative Phase Imaging Using Digital Holographic Microscopy Reliably Assesses Morphology and Reflects Elastic Properties of Fibrotic Intestinal Tissue

Figure 4

Significant correlation between the refractive index (RI) determined by digital holography microscopy (DHM) and the immunofluroescence-intensity of fibrosis markers. (A–C) The RI of the intestinal tissue (mucosa, submucosa and muscularis propria) determined by DHM in 30 surgical resection specimens significantly correlated with the light intensity of fibrosis markers determined by immunofluorescence studies (all p < 0.001). (D) The strongest correlation was found between the RI and the average immunofluorescence-intensity of all three fibrosis markers (p < 0.001; R2 = 0.477). Statistical analysis was performed using Pearson-correlation. Two-sided p values < 0.05 were considered statistically significant.

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