Table 1 –mRNA expression of genes involved in NAD+ metabolism.

From: Extracellular NAD+ enhances PARP-dependent DNA repair capacity independently of CD73 activity

 

Gene Symbol

Protein symbol

LN428

T98G

A375

G09607

HCT116

MCF-7

MDA-MB-231

NCI.H460

U87MG

De novo pathway

AFMID

AFMID

40.89

45.79

33.45

66.57

204.48

55.25

51.44

73.62

57.21

HAAO

HAAO

29.49

37.08

25.96

24.75

25.32

25.01

26.06

27.74

26.41

IDO1

IDO1

14.88

18.55

10.28

10.23

11.46

11.02

11.57

10.55

10.92

IDO2

IDO2

29.80

33.33

28.09

26.69

31.94

26.52

28.48

31.50

28.45

KMO

KMO

83.45

14.30

7.36

7.41

7.82

7.07

7.65

8.99

7.57

KYNU

KYNU

57.84

2249.41

170.52

7.52

7.02

1983.97

483.52

2515.09

698.91

QPRT

QPRT

52.12

38.65

29.42

19.19

17.89

178.43

18.17

19.16

64.10

TDO2

TDO2

17.21

33.97

11.03

11.17

8.72

8.01

13.09

297.70

607.43

Salvage pathway

NMRK1

NRK1

17.32

15.70

13.43

107.94

19.98

51.06

15.13

92.69

64.43

NMRK2

NRK2

17.81

17.06

14.38

13.60

14.25

13.87

15.07

13.26

13.58

NADK

NADK

277.26

122.72

282.80

245.63

275.73

324.26

168.87

174.61

206.54

NADSYN1

NADSYN1

55.78

89.77

52.15

83.67

56.34

227.16

88.74

87.07

147.14

NAMPT

NAMPT

576.38

806.05

835.90

306.31

320.68

205.40

690.60

2235.86

1237.03

NAPRT

NAPRT1

30.58

43.24

34.38

160.61

254.06

123.02

118.04

42.58

33.53

NMNAT1

NMNAT1

40.97

25.39

57.95

49.21

52.60

46.96

39.11

27.37

73.35

NMNAT2

NMNAT2

61.85

66.41

36.01

63.98

19.56

38.67

132.46

78.27

197.11

NMNAT3

NMNAT3

47.09

31.96

18.85

18.99

32.23

24.09

20.71

20.94

19.06

PNP

PNP

851.34

221.99

394.01

656.57

648.50

634.86

1424.01

1122.68

383.69

NAD+ consuming enzymes

BST1

CD157

19.21

8.86

8.31

138.09

9.43

7.45

11.74

111.67

25.21

CD38

CD38

10.62

9.63

9.04

622.73

8.14

8.72

8.74

8.36

8.41

ENTPD1

CD39

17.57

18.20

17.15

16.72

19.28

16.32

21.65

18.77

16.39

NNMT

NNMT

448.21

731.95

1127.63

565.88

24.03

18.71

26.03

154.81

410.01

NT5E

CD73

1504.20

19.21

689.83

1438.59

469.60

90.63

2247.53

379.95

1033.97

PARP1

PARP1

518.96

604.91

398.42

1033.13

639.85

415.14

680.80

794.18

129.65

PARP2

PARP2

267.44

206.39

206.23

299.33

412.53

266.18

385.40

353.05

119.51

PARP3

PARP3

196.23

177.90

163.03

238.20

127.02

38.35

141.02

116.70

239.57

SIRT1

SIRT1

395.87

311.12

182.53

360.42

411.73

326.82

342.83

341.26

313.82

SIRT2

SIRT2

332.45

228.72

230.47

255.80

250.11

513.48

338.45

323.30

299.61

SIRT3

SIRT3

208.19

278.25

94.12

98.92

169.51

87.97

120.82

149.62

129.08

SIRT4

SIRT4

18.43

21.91

14.83

14.85

17.95

13.93

14.91

14.86

13.02

SIRT5

SIRT5

62.25

47.84

16.97

36.65

58.62

47.85

52.25

31.19

30.79

SIRT6

SIRT6

63.69

67.00

64.35

57.34

65.25

75.76

60.34

60.45

70.75

SIRT7

SIRT7

268.57

249.30

116.31

225.22

271.26

263.94

188.41

180.28

236.76

TNKS

TNKS

71.42

196.13

155.65

92.31

165.27

87.94

77.52

78.46

220.74

TNKS2

TNKS2

28.17

128.73

96.43

137.27

175.87

84.43

109.39

103.54

121.72

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